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pentobarbital will reduce the level or outcome of ramelteon by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.pentobarbital decreases amounts of panobinostat by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can cut down panobinostat levels by ~70% and lead to rem